Sak Uwong Sak Uwit Policy: Environmental Conservation Strategy
نویسندگان
چکیده
منابع مشابه
SAK/PLK4 Is Required for Centriole Duplication and Flagella Development
BACKGROUND SAK/PLK4 is a distinct member of the polo-like kinase family. SAK-/- mice die during embryogenesis, whereas SAK+/- mice develop liver and lung tumors and SAK+/- MEFs show mitotic abnormalities. However, the mechanism underlying these phenotypes is still not known. RESULTS Here, we show that downregulation of SAK in Drosophila cells, by mutation or RNAi, leads to loss of centrioles,...
متن کاملPlk4/SAK/ZYG-1 in the regulation of centriole duplication
Centrioles organize both centrosomes and cilia. Centriole duplication is tightly regulated and coordinated with the cell cycle to limit duplication to only once per cell cycle. Defects in centriole number and structure are commonly found in cancer. Plk4/SAK and the functionally related Caenorhabditis elegans ZYG-1 kinases initiate centriole duplication. Several recent studies have elucidated th...
متن کاملLate mitotic failure in mice lacking Sak, a polo-like kinase
Polo-like kinases in yeast, flies, and mammals regulate key events in mitosis. Such events include spindle formation at G2/M, the anaphase-promoting complex (APC) at the exit from mitosis, the cleavage structure at cytokinesis, and DNA damage checkpoints in G2/M. Polo-like kinases are distinguished by two C-terminal polo box (pb) motifs, which localize the enzymes to mitotic structures. We prev...
متن کاملThe SCFSlimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication
Restricting centriole duplication to once per cell cycle is critical for chromosome segregation and genomic stability, but the mechanisms underlying this block to reduplication are unclear. Genetic analyses have suggested an involvement for Skp/Cullin/F box (SCF)-class ubiquitin ligases in this process. In this study, we describe a mechanism to prevent centriole reduplication in Drosophila mela...
متن کاملSak and Sak4 recombinases are required for bacteriophage replication in Staphylococcus aureus
DNA-single strand annealing proteins (SSAPs) are recombinases frequently encoded in the genome of many bacteriophages. As SSAPs can promote homologous recombination among DNA substrates with an important degree of divergence, these enzymes are involved both in DNA repair and in the generation of phage mosaicisms. Here, analysing Sak and Sak4 as representatives of two different families of SSAPs...
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ژورنال
عنوان ژورنال: Walisongo Law Review (Walrev)
سال: 2019
ISSN: 2722-0400,2715-3347
DOI: 10.21580/walrev.2019.2.2.4825